The Life and Strange Surprizing Adventures of Robinson Crusoe, of York, Mariner • Paragraph 1943
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A great many of the properties possessed by plants are of the most extraordinary and unsuspected nature. The roots of the Madder (_Rubia tinctorum_), for instance, when they are eaten by swine or other animals, change the colour of their bones, which become pink. This curious property has actually been made useful, for physiologists have employed madder in the study of the growth and development of bone.